Experimental Biology and Medicine | New and Recent Articles https://www.ebm-journal.org/journals/experimental-biology-and-medicine RSS Feed for Experimental Biology and Medicine | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-06-23T20:24:44.64+00:00 60 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10979 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10979 <![CDATA[Phenotypic profiling of Pathogen Box compounds MMV667494 and MMV028694 in bloodstream-form Trypanosoma brucei brucei]]> 2026-06-12T00:00:00Z Original Research Pearl Ihuoma AkazueNeils Ben QuashieSue VaughanHarry P. de KoningTheresa Manful Gwira 10). Growth profiling demonstrated dose-dependent inhibition of parasite proliferation, with evidence of trypanocidal activity at higher concentrations and longer exposure times. Treatment resulted in increased populations of phosphatidylserine-exposed and membrane-compromised cells, which is consistent with apoptosis-like phenotypes in trypanosomes. Although both compounds induced mitochondrial membrane depolarization in treated T. b. brucei cells, this effect was observed predominantly in a subpopulation of cells and is therefore unlikely to represent the primary cause of cell death. Increased mitochondrial production of reactive oxygen species and altered cell-cycle progression were also observed, which might indicate disruption of key cellular processes. These findings shows that MMV667494 and MMV028694 are selective antitrypanosomal compounds and their activities are associated with induce apoptosis-like features, cell-cycle disruption, and mitochondrial stress signatures in bloodstream-form T. b. brucei. These findings provide phenotypic insights into the activity of the compounds, warranting further target deconvolution and optimization, although validation in human-infective subspecies and in vivo systems will be required.]]> https://www.ebm-journal.org/articles/10.3389/ebm.2026.10941 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10941 <![CDATA[Nicotinamide adenine dinucleotide phosphate oxidase 4 in lung disease: a review of its biology and therapeutic potential]]> 2026-06-12T00:00:00Z Review Yilin WangTianru BenJianjiang FangZengpan LiJinhua DingLiyan XuKai LinLi Jiang https://www.ebm-journal.org/articles/10.3389/ebm.2026.10868 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10868 <![CDATA[High systolic blood pressure and stroke: evidence from the NHANES 1999–2023 and global burden of disease 2021]]> 2026-06-08T00:00:00Z Original Research LuYi TangBoWen YangPeiWen LiYingQi ChenYi LiuTing WangXiaohan Ye https://www.ebm-journal.org/articles/10.3389/ebm.2026.11038 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11038 <![CDATA[Scaling human liver microphysiological systems: implementing a higher-throughput liver acinus microphysiological system platform]]> 2026-05-22T00:00:00Z Original Research Dillon C. GavlockMichael W. CastiglioneAllen WangMahboubeh VarmazyadLawrence A. VernettiMark E. SchurdakD. Lansing TaylorJacquelyn A. BrownMark T. Miedel https://www.ebm-journal.org/articles/10.3389/ebm.2026.11094 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11094 <![CDATA[Race, oxygen exposure, and retinopathy of prematurity: re-examining a persistent epidemiologic paradox]]> 2026-05-18T00:00:00Z Mini Review Beryl ZhouSarah H. RodriguezAlexis WarrenDimitra Skondra https://www.ebm-journal.org/articles/10.3389/ebm.2026.10987 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10987 <![CDATA[Peripheral immune cells and glycation indices as potential diagnostic biomarkers in amyotrophic lateral sclerosis]]> 2026-05-13T00:00:00Z Original Research Xue YangJing YangRui LiHui DongYaling Liu https://www.ebm-journal.org/articles/10.3389/ebm.2026.10945 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10945 <![CDATA[Antibody-mediated immune responses and cardiovascular disease: a Mendelian randomization study]]> 2026-05-12T00:00:00Z Original Research Yi LiJiuqi FanLirong Wu https://www.ebm-journal.org/articles/10.3389/ebm.2026.10922 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10922 <![CDATA[Causal relationship between oral diseases and hypertension: a Mendelian randomization study]]> 2026-05-07T00:00:00Z Original Research Bofan QianZhiwen Fang https://www.ebm-journal.org/articles/10.3389/ebm.2026.10997 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10997 <![CDATA[Ferroptosis and futile recanalization after mechanical thrombectomy in acute ischemic stroke: mechanisms, risk factors, predictive models and therapeutic interventions]]> 2026-05-01T00:00:00Z Review Yuexin WuCuiying ZhangYangyang PengLonglong Liu https://www.ebm-journal.org/articles/10.3389/ebm.2026.10946 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10946 <![CDATA[Sacubitril valsartan combined with bisoprolol reduces doxorubicin-induced cardiotoxicity in rats by attenuating oxidative stress]]> 2026-04-28T00:00:00Z Original Research Ping LiuHui YangRunqi LiHui HuangMin Xu https://www.ebm-journal.org/articles/10.3389/ebm.2026.10988 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10988 <![CDATA[Training the next-generation of biomedical scientists through artificial intelligence-driven education and research in pharmacology and pharmaceutical sciences]]> 2026-04-22T00:00:00Z Mini Review Santosh KumarRitu KarwasraWeinan ZhouJayaraman SeetharamanBhupesh Singla https://www.ebm-journal.org/articles/10.3389/ebm.2026.10827 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10827 <![CDATA[Elevated ApoC3 levels in cerebrospinal fluid predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage]]> 2026-04-17T00:00:00Z Original Research Bin TongJunjie WangJiarui ChenQia ZhangZhouhan XuKaichuang YangXiaomin Chen https://www.ebm-journal.org/articles/10.3389/ebm.2026.11021 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11021 <![CDATA[CAR T cell engineering approaches to minimise toxicities]]> 2026-04-15T00:00:00Z Mini Review Elizabeth HogbenAnna SchurichCharlotte Graham https://www.ebm-journal.org/articles/10.3389/ebm.2026.10850 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10850 <![CDATA[Lymphatic pumping technique in mice alters blood parameters and metastatic melanoma in an age-dependent manner]]> 2026-03-30T00:00:00Z Original Research Christopher WalshMatthew KirsteinElise WagnerEmily ScottJerome WalshShashank ReddyNathan HoggardArshad AhmadReetobrata BasuSam MathesYanrong QianJohn J. Kopchick https://www.ebm-journal.org/articles/10.3389/ebm.2026.10857 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10857 <![CDATA[Towards a standardized diabetic prolonged wound healing model in hairless SKH1 mice]]> 2026-03-20T00:00:00Z Original Research Elle KoivunotkoJulia MonolaChris S. PridgeonJere LindenRiina HarjumäkiEmrah YatkinMari MadetojaMarjo Yliperttula https://www.ebm-journal.org/articles/10.3389/ebm.2026.10933 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10933 <![CDATA[Genetics of epilepsy]]> 2026-03-19T00:00:00Z Review Kynen PiacentiniAthanasios GaitatzisSulev Kõks https://www.ebm-journal.org/articles/10.3389/ebm.2026.10907 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10907 <![CDATA[A novel platelet-rich plasma clinically induces reliable, rapid, long-term chronic peripheral neuropathic pain elimination]]> 2026-03-13T00:00:00Z Brief Communication Damien P. KufflerOnix ReyesIvan J. SosaChristian A. Foy https://www.ebm-journal.org/articles/10.3389/ebm.2026.10796 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10796 <![CDATA[Enhanced oxidative stress resilience in C. elegans acox-1.1 mutants through CTL-3 and proteasomal regulation]]> 2026-03-13T00:00:00Z Brief Communication Woori BaeMina NormanMyon Hee Lee https://www.ebm-journal.org/articles/10.3389/ebm.2026.10679 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10679 <![CDATA[Low dose thirdhand smoke exposure enhances platelet functional responses in mice]]> 2026-03-12T00:00:00Z Original Research Precious O. BadejoAhmed B. AlarabiHamdy E. A. AliLanam MillicanReina De La PazShelby S. UmphresSadia KamalFatima Z. AlshboolFadi T. Khasawneh https://www.ebm-journal.org/articles/10.3389/ebm.2026.10867 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10867 <![CDATA[Metabolomics-guided identification of bioactive phytometabolites from South African plants targeting neuroblastoma]]> 2026-03-05T00:00:00Z Original Research Mmei Cheryl MotshudiClarissa Marcelle NaidooChikwelu Lawrence ObiBenson Chucks IwerieborEarl PrinslooMuhammad Sulaiman ZubairNqobile Monate Mkolo