Experimental Biology and Medicine | New and Recent Articles https://www.ebm-journal.org/journals/experimental-biology-and-medicine RSS Feed for Experimental Biology and Medicine | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-08-03T08:15:06.489+00:00 60 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10923 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10923 <![CDATA[Causal association between clonal hematopoiesis indeterminate potential and cancer: a Mendelian randomization study]]> 2026-07-27T00:00:00Z Original Research Juan JinQian PuChengrong WuYu LeiYaxin HuXiuju YangJinghui HuangFangfang WuLi XiaoLei Yu https://www.ebm-journal.org/articles/10.3389/ebm.2026.11114 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11114 <![CDATA[Novel perspective on immune cell regulation in gastrointestinal inflammation: the role of extracellular vesicles and therapeutic prospects]]> 2026-07-17T00:00:00Z Review Jianshu WangJunxuan XuZilu CuiJing Wu https://www.ebm-journal.org/articles/10.3389/ebm.2026.10948 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10948 <![CDATA[Genetic evidence for causal relationships between brain functional networks and domain-specific recovery after nondisabling ischemic stroke]]> 2026-07-13T00:00:00Z Original Research Huan CaiZhenchun HuangJialin LiangHao ZhangZhonghua Liu https://www.ebm-journal.org/articles/10.3389/ebm.2026.11058 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11058 <![CDATA[Gut microbiota and polyendocrine metabolic ovarian syndrome: an integrated gut–metabolism–endocrine–ovary axis]]> 2026-07-10T00:00:00Z Review Shengyue JinMenglei ZhuYiyang LuJia ZhaoJiayi ZhuXiaohong Fang https://www.ebm-journal.org/articles/10.3389/ebm.2026.11099 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11099 <![CDATA[A whole-transcriptome analysis of differentially expressed genes, transcripts, and transcript usage in blood samples from Parkinson’s disease patients]]> 2026-07-08T00:00:00Z Original Research Sulev KoksMari MuldmaaJack PriceLuke WhileyMaili JakobsonLewis SingletonDenise HowtingAbigail L. PfaffAbha ChopraMark WatsonKatrin SikkPille Taba https://www.ebm-journal.org/articles/10.3389/ebm.2026.11060 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11060 <![CDATA[Transcriptomics-based identification of shared biomarkers across type 2 diabetes, mild cognitive impairment, and uric acid metabolism]]> 2026-07-06T00:00:00Z Original Research Yan LiuDongmei KangYuan Lei https://www.ebm-journal.org/articles/10.3389/ebm.2026.11128 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11128 <![CDATA[Mitochondrial transfer and mesenchymal stem cells in ophthalmology: current evidence and therapeutic implications]]> 2026-06-30T00:00:00Z Mini Review Xiaoli LiuMingqi ZhangZhuoshi Wang https://www.ebm-journal.org/articles/10.3389/ebm.2026.11069 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11069 <![CDATA[Advances in research on pharmacological mechanisms of anatabine: from nicotinic modulation to multitarget therapeutic potential]]> 2026-06-29T00:00:00Z Review Xiaonan LiXiaomin LiuHuaquan ShengJianfeng GuoLeihao ZhangTing FeiYihan Gao https://www.ebm-journal.org/articles/10.3389/ebm.2026.10979 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10979 <![CDATA[Phenotypic profiling of Pathogen Box compounds MMV667494 and MMV028694 in bloodstream-form Trypanosoma brucei brucei]]> 2026-06-12T00:00:00Z Original Research Pearl Ihuoma AkazueNeils Ben QuashieSue VaughanHarry P. de KoningTheresa Manful Gwira 10). Growth profiling demonstrated dose-dependent inhibition of parasite proliferation, with evidence of trypanocidal activity at higher concentrations and longer exposure times. Treatment resulted in increased populations of phosphatidylserine-exposed and membrane-compromised cells, which is consistent with apoptosis-like phenotypes in trypanosomes. Although both compounds induced mitochondrial membrane depolarization in treated T. b. brucei cells, this effect was observed predominantly in a subpopulation of cells and is therefore unlikely to represent the primary cause of cell death. Increased mitochondrial production of reactive oxygen species and altered cell-cycle progression were also observed, which might indicate disruption of key cellular processes. These findings shows that MMV667494 and MMV028694 are selective antitrypanosomal compounds and their activities are associated with induce apoptosis-like features, cell-cycle disruption, and mitochondrial stress signatures in bloodstream-form T. b. brucei. These findings provide phenotypic insights into the activity of the compounds, warranting further target deconvolution and optimization, although validation in human-infective subspecies and in vivo systems will be required.]]> https://www.ebm-journal.org/articles/10.3389/ebm.2026.10941 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10941 <![CDATA[Nicotinamide adenine dinucleotide phosphate oxidase 4 in lung disease: a review of its biology and therapeutic potential]]> 2026-06-12T00:00:00Z Review Yilin WangTianru BenJianjiang FangZengpan LiJinhua DingLiyan XuKai LinLi Jiang https://www.ebm-journal.org/articles/10.3389/ebm.2026.10868 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10868 <![CDATA[High systolic blood pressure and stroke: evidence from the NHANES 1999–2023 and global burden of disease 2021]]> 2026-06-08T00:00:00Z Original Research LuYi TangBoWen YangPeiWen LiYingQi ChenYi LiuTing WangXiaohan Ye https://www.ebm-journal.org/articles/10.3389/ebm.2026.11038 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11038 <![CDATA[Scaling human liver microphysiological systems: implementing a higher-throughput liver acinus microphysiological system platform]]> 2026-05-22T00:00:00Z Original Research Dillon C. GavlockMichael W. CastiglioneAllen WangMahboubeh VarmazyadLawrence A. VernettiMark E. SchurdakD. Lansing TaylorJacquelyn A. BrownMark T. Miedel https://www.ebm-journal.org/articles/10.3389/ebm.2026.11094 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11094 <![CDATA[Race, oxygen exposure, and retinopathy of prematurity: re-examining a persistent epidemiologic paradox]]> 2026-05-18T00:00:00Z Mini Review Beryl ZhouSarah H. RodriguezAlexis WarrenDimitra Skondra https://www.ebm-journal.org/articles/10.3389/ebm.2026.10987 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10987 <![CDATA[Peripheral immune cells and glycation indices as potential diagnostic biomarkers in amyotrophic lateral sclerosis]]> 2026-05-13T00:00:00Z Original Research Xue YangJing YangRui LiHui DongYaling Liu https://www.ebm-journal.org/articles/10.3389/ebm.2026.10945 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10945 <![CDATA[Antibody-mediated immune responses and cardiovascular disease: a Mendelian randomization study]]> 2026-05-12T00:00:00Z Original Research Yi LiJiuqi FanLirong Wu https://www.ebm-journal.org/articles/10.3389/ebm.2026.10922 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10922 <![CDATA[Causal relationship between oral diseases and hypertension: a Mendelian randomization study]]> 2026-05-07T00:00:00Z Original Research Bofan QianZhiwen Fang https://www.ebm-journal.org/articles/10.3389/ebm.2026.10997 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10997 <![CDATA[Ferroptosis and futile recanalization after mechanical thrombectomy in acute ischemic stroke: mechanisms, risk factors, predictive models and therapeutic interventions]]> 2026-05-01T00:00:00Z Review Yuexin WuCuiying ZhangYangyang PengLonglong Liu https://www.ebm-journal.org/articles/10.3389/ebm.2026.10946 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10946 <![CDATA[Sacubitril valsartan combined with bisoprolol reduces doxorubicin-induced cardiotoxicity in rats by attenuating oxidative stress]]> 2026-04-28T00:00:00Z Original Research Ping LiuHui YangRunqi LiHui HuangMin Xu https://www.ebm-journal.org/articles/10.3389/ebm.2026.10988 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10988 <![CDATA[Training the next-generation of biomedical scientists through artificial intelligence-driven education and research in pharmacology and pharmaceutical sciences]]> 2026-04-22T00:00:00Z Mini Review Santosh KumarRitu KarwasraWeinan ZhouJayaraman SeetharamanBhupesh Singla https://www.ebm-journal.org/articles/10.3389/ebm.2026.10827 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10827 <![CDATA[Elevated ApoC3 levels in cerebrospinal fluid predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage]]> 2026-04-17T00:00:00Z Original Research Bin TongJunjie WangJiarui ChenQia ZhangZhouhan XuKaichuang YangXiaomin Chen