Experimental Biology and Medicine | New and Recent Articles https://www.ebm-journal.org/journals/experimental-biology-and-medicine RSS Feed for Experimental Biology and Medicine | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-09-25T14:25:53.872+00:00 60 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10935 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10935 <![CDATA[CERKL-related inherited retinal dystrophy in a Brazilian cohort: genotype-phenotype correlation]]> 2026-09-23T00:00:00Z Original Research E. S. YasakiM. V. SallesF. L. MottaJ. M. F. Sallum T (p.Arg283) nonsense variant in exon 6 was the most common variant in this cohort, identified in 24 homozygous out of 52 individuals and in 12 compound heterozygous. The phenotype of CERKL-related IRD is CORD with an early age of presentation and fast decrease in visual acuity. In addition to OMIM classifying this gene as an retinitis pigmentosa IRD, we believe CERKL has CORD phenotype, in concordance with evidence described in the literature.]]> https://www.ebm-journal.org/articles/10.3389/ebm.2026.10940 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10940 <![CDATA[Primary biliary cirrhosis and inflammatory bowel disease: a two-sample bidirectional Mendelian randomization study]]> 2026-09-17T00:00:00Z Original Research Mingyi YangJiale XieJing HuPengfei WenLin LiuZhi YangMing ZhangChangliang ZhuYani Su 0.003, OR 95% CI = 0.788 [0.672–0.924]), whereas no significant effect was detected from CD on PBC (P = 0.431, OR 95% CI = 0.956 [0.856–1.068]). We then extended the analysis to the overall IBD phenotype. The forward MR demonstrated a significant positive genetic relationship between PBC on IBD (P < 0.001, OR 95% CI = 1.076 [1.042–1.110]). Conversely, the reverse MR did not support a causal effect of IBD on PBC (P = 0.357, OR 95% CI = 0.898 [0.714–1.129]). The robustness of all these findings was confirmed by comprehensive sensitivity analyses, which showed no evidence of heterogeneity, horizontal pleiotropy, or undue influence from individual instrumental variables. Our MR analysis demonstrates that PBC serves as a genetic determinant of IBD as a whole and of UC/CD separately, whereas reverse causation is limited to a protective effect of UC on PBC. This direction-dependent and subtype-specific causal architecture provides novel insights into the shared etiological pathways between PBC and IBD.]]> https://www.ebm-journal.org/articles/10.3389/ebm.2026.11238 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11238 <![CDATA[The causal relationship between antibody-mediated immune responses to infections and Graves’ disease: a bi-directional Mendelian randomization analysis]]> 2026-09-16T00:00:00Z Original Research Xinwei ZhangWenyu XuZhou LiuJinan ZhangXiaorong Yang https://www.ebm-journal.org/articles/10.3389/ebm.2026.11023 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11023 <![CDATA[Causal effects of gut microbiota on functional gastrointestinal disorders: a bidirectional Mendelian randomization study]]> 2026-09-10T00:00:00Z Original Research Yutong ChengQiuai ShuZiwei WangJian WuYuxin PengJiale XieXiru LiangZhiwei TaoHaitao ShiZhongcao WeiJinhai WangNing Xie https://www.ebm-journal.org/articles/10.3389/ebm.2026.11199 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11199 <![CDATA[Maternal high-fat diet and risk of cardiovascular disease in offspring: a review of mechanisms, controversies, and interventions]]> 2026-09-01T00:00:00Z Review Heyu MengJianjun RuanQing WangFanbo Meng https://www.ebm-journal.org/articles/10.3389/ebm.2026.11246 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11246 <![CDATA[Extracellular vesicles for abdominal aortic aneurysm: mechanisms, therapeutic potential, and translational challenges]]> 2026-08-28T00:00:00Z Review Huibo MaZongyou XieYihang CaiFangda LiJianqiang WuYuehong Zheng https://www.ebm-journal.org/articles/10.3389/ebm.2026.11146 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11146 <![CDATA[The interaction between oxidative stress and Schwann cells]]> 2026-08-27T00:00:00Z Review Sihan YangZijun ZhangQing LiaoQipeng OuyangYongyou YeWei LuZhendong Jiang https://www.ebm-journal.org/articles/10.3389/ebm.2026.11144 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11144 <![CDATA[Altered serum interleukin-4 and monocyte chemoattractant protein-3 levels are associated with generalized anxiety disorder: a case-control study]]> 2026-08-26T00:00:00Z Original Research Most. Humayra Binta RashidMehedi IslamSardar Mohammad Ashraful IslamMd. Rabiul Islam https://www.ebm-journal.org/articles/10.3389/ebm.2026.10915 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10915 <![CDATA[The value of serum exosomal miRNA signature profiles for the early diagnosis of feline infectious peritonitis]]> 2026-08-11T00:00:00Z Original Research Hongxia GuHuisheng Wu https://www.ebm-journal.org/articles/10.3389/ebm.2026.10902 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10902 <![CDATA[XPA confers ability of endonucleases to act processively and to incise damaged nucleosomal DNA]]> 2026-08-11T00:00:00Z Review Muriel W. LambertW. Clark Lambert https://www.ebm-journal.org/articles/10.3389/ebm.2026.11192 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11192 <![CDATA[The role and mechanism of neutrophils in oncolytic virus therapy]]> 2026-08-06T00:00:00Z Review Baixian HuangQixin YangRuixue WangChaochao Zhao https://www.ebm-journal.org/articles/10.3389/ebm.2026.10958 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10958 <![CDATA[Correction: Protective effects of berberine-loaded chitosan/solid lipid nanoparticles in streptozotocin-induced gestational diabetes mellitus rats]]> 2026-08-03T00:00:00Z Correction EBM Production Office https://www.ebm-journal.org/articles/10.3389/ebm.2026.10923 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10923 <![CDATA[Causal association between clonal hematopoiesis indeterminate potential and cancer: a Mendelian randomization study]]> 2026-07-27T00:00:00Z Original Research Juan JinQian PuChengrong WuYu LeiYaxin HuXiuju YangJinghui HuangFangfang WuLi XiaoLei Yu https://www.ebm-journal.org/articles/10.3389/ebm.2026.11114 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11114 <![CDATA[Novel perspective on immune cell regulation in gastrointestinal inflammation: the role of extracellular vesicles and therapeutic prospects]]> 2026-07-17T00:00:00Z Review Jianshu WangJunxuan XuZilu CuiJing Wu https://www.ebm-journal.org/articles/10.3389/ebm.2026.10948 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10948 <![CDATA[Genetic evidence for causal relationships between brain functional networks and domain-specific recovery after nondisabling ischemic stroke]]> 2026-07-13T00:00:00Z Original Research Huan CaiZhenchun HuangJialin LiangHao ZhangZhonghua Liu https://www.ebm-journal.org/articles/10.3389/ebm.2026.11058 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11058 <![CDATA[Gut microbiota and polyendocrine metabolic ovarian syndrome: an integrated gut–metabolism–endocrine–ovary axis]]> 2026-07-10T00:00:00Z Review Shengyue JinMenglei ZhuYiyang LuJia ZhaoJiayi ZhuXiaohong Fang https://www.ebm-journal.org/articles/10.3389/ebm.2026.11099 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11099 <![CDATA[A whole-transcriptome analysis of differentially expressed genes, transcripts, and transcript usage in blood samples from Parkinson’s disease patients]]> 2026-07-08T00:00:00Z Original Research Sulev KoksMari MuldmaaJack PriceLuke WhileyMaili JakobsonLewis SingletonDenise HowtingAbigail L. PfaffAbha ChopraMark WatsonKatrin SikkPille Taba https://www.ebm-journal.org/articles/10.3389/ebm.2026.11060 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11060 <![CDATA[Transcriptomics-based identification of shared biomarkers across type 2 diabetes, mild cognitive impairment, and uric acid metabolism]]> 2026-07-06T00:00:00Z Original Research Yan LiuDongmei KangYuan Lei https://www.ebm-journal.org/articles/10.3389/ebm.2026.11128 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11128 <![CDATA[Mitochondrial transfer and mesenchymal stem cells in ophthalmology: current evidence and therapeutic implications]]> 2026-06-30T00:00:00Z Mini Review Xiaoli LiuMingqi ZhangZhuoshi Wang https://www.ebm-journal.org/articles/10.3389/ebm.2026.11069 https://www.ebm-journal.org/articles/10.3389/ebm.2026.11069 <![CDATA[Advances in research on pharmacological mechanisms of anatabine: from nicotinic modulation to multitarget therapeutic potential]]> 2026-06-29T00:00:00Z Review Xiaonan LiXiaomin LiuHuaquan ShengJianfeng GuoLeihao ZhangTing FeiYihan Gao