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        <title>Experimental Biology and Medicine | Bionanoscience section | New and Recent Articles</title>
        <link>https://www.ebm-journal.org/journals/experimental-biology-and-medicine/sections/bionanoscience</link>
        <description>RSS Feed for Bionanoscience section in the Experimental Biology and Medicine journal | New and Recent Articles</description>
        <language>en-us</language>
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        <pubDate>2026-04-10T23:30:37.208+00:00</pubDate>
        <ttl>60</ttl>
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        <guid isPermaLink="true">https://www.ebm-journal.org/articles/10.3389/ebm.2026.10793</guid>
        <link>https://www.ebm-journal.org/articles/10.3389/ebm.2026.10793</link>
        <title><![CDATA[Pulmonary injury following exposure to amorphous silicon dioxide nanoparticles in Golden Syrian Hamsters]]></title>
        <pubdate>2026-01-26T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Rachel P. Renda</author><author>Joseph M. Cerreta</author>
        <description><![CDATA[Amorphous silicon dioxide nanoparticles (SiO2 NPs) are abundant within the earth’s crust and can be released into the air through industrial and manufacturing activities. Such materials are often used in industrial processes, in pharmaceutical and in the cosmetic industries. Amorphous SiO2 NPs are pulmonary toxicants; however, the mechanism of toxicity is uncertain. In the current study, toxicity of SiO2 NPs was assessed using inhalation exposure in an in vivo system to study a possible mechanism of pulmonary injury. Golden Syrian Hamsters were divided into 4 groups: 1- room air control, 2- vehicle control, 3- low concentration (6 mg/m3) and 4- high concentration (12 mg/m3). Hamsters were treated for 4 h a day for 8 days. Bronchoalveolar Lavage Fluid (BALF) analysis found increases in total cell counts (p < 0.0001), neutrophils (p < 0.0001), lymphocytes (p < 0.001), eosinophils (p < 0.01), multinucleated macrophages (p < 0.01), total protein (p < 0.0001), alkaline phosphatase (p < 0.0001), and lactate dehydrogenase (p < 0.001) in the high concentration group. Histopathological analysis found an increase in air space, quantified by Mean Linear Intercept (p < 0.0001), and a significant increase in TUNEL positive cells (p < 0.001), in the high concentration group. SEM and TEM found structural alterations to the lung tissue including increase in the number holes in the alveolar walls and in apoptotic bodies within tissue. Caspase 3 (p < 0.05), and 8 (p < 0.05), were significantly increased along with cellular inflammation markers TNF-α (p < 0.05), and HSP70 (p < 0.05) in the high concentration group. Results of the study indicate exposure to SiO2 NPs may induce extrinsic apoptotic pathway, leading to tissue damage and significant airspace enlargement.]]></description>
      </item><item>
        <guid isPermaLink="true">https://www.ebm-journal.org/articles/10.3389/ebm.2025.10517</guid>
        <link>https://www.ebm-journal.org/articles/10.3389/ebm.2025.10517</link>
        <title><![CDATA[Correlation study of CAR, PLR, NLR with the prognosis of cardiogenic cerebral embolism patients]]></title>
        <pubdate>2025-06-17T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Xiaojing Du</author><author>Xiaohui Li</author><author>Sheng Yue</author><author>Yuzhen Sun</author><author>Mengzhen Zhao</author><author>Lingshan Zhou</author><author>Xingwei Wang</author><author>Yapan Yang</author>
        <description><![CDATA[This study explored the association between inflammatory biomarkers—C-reactive protein to albumin ratio (CAR), platelet to lymphocyte ratio (PLR), and neutrophil to lymphocyte ratio (NLR)—and the prognosis of patients with cardiogenic cerebral embolism (CCE). We retrospectively analyzed data from 80 CCE patients diagnosed between June 2020 and June 2024, categorizing them into favorable and unfavorable prognosis groups based on outcomes such as death, recurrence, and disability. The CAR, PLR, and NLR values were calculated from routine blood tests, and statistical analyses, including Spearman correlation, multivariate logistic regression, and ROC curve analysis, were performed to examine their prognostic significance. Results showed that the unfavorable prognosis group had significantly higher CAR, PLR, and NLR values compared to the favorable group (P < 0.05). Spearman correlation analysis revealed positive associations between these biomarkers and prognosis (r = 0.319 for CAR, 0.238 for PLR, 0.251 for NLR, all P < 0.05). Multivariate analysis identified CAR and NLR as independent risk factors for unfavorable prognosis (OR = 1.034 for CAR, OR = 3.887 for NLR). ROC analysis determined optimal cutoff values for CAR (>0.74), PLR (>160.00), and NLR (>3.53) to predict unfavorable prognosis with AUCs of 0.796, 0.694, and 0.705, respectively. The combined biomarker test yielded an AUC of 0.899. Kaplan-Meier survival analysis indicated significantly lower survival rates for patients with higher levels of CAR, PLR, and NLR (P < 0.05). In conclusion, elevated CAR, PLR, and NLR are reliable indicators of a poor prognosis in CCE patients.]]></description>
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        <guid isPermaLink="true">https://www.ebm-journal.org/articles/10.3389/ebm.2024.10055</guid>
        <link>https://www.ebm-journal.org/articles/10.3389/ebm.2024.10055</link>
        <title><![CDATA[Internalization of transferrin-tagged Myxococcus xanthus encapsulins into mesenchymal stem cells]]></title>
        <pubdate>2024-05-07T00:00:00Z</pubdate>
        <category>Original Research</category>
        <author>Anna N. Gabashvili</author><author>Natalya A. Alexandrushkina</author><author>Elizaveta N. Mochalova</author><author>Daria V. Goliusova</author><author>Ekaterina N. Sapozhnikova</author><author>Pavel I. Makarevich</author><author>Petr I. Nikitin</author>
        <description><![CDATA[Currently, various functionalized nanocarrier systems are extensively studied for targeted delivery of drugs, peptides, and nucleic acids. Joining the approaches of genetic and chemical engineering may produce novel carriers for precise targeting different cellular proteins, which is important for both therapy and diagnosis of various pathologies. Here we present the novel nanocontainers based on vectorized genetically encoded Myxococcus xanthus (Mx) encapsulin, confining a fluorescent photoactivatable mCherry (PAmCherry) protein. The shells of such encapsulins were modified using chemical conjugation of human transferrin (Tf) prelabeled with a fluorescein-6 (FAM) maleimide acting as a vector. We demonstrate that the vectorized encapsulin specifically binds to transferrin receptors (TfRs) on the membranes of mesenchymal stromal/stem cells (MSCs) followed by internalization into cells. Two spectrally separated fluorescent signals from Tf-FAM and PAmCherry are clearly distinguishable and co-localized. It is shown that Tf-tagged Mx encapsulins are internalized by MSCs much more efficiently than by fibroblasts. It has been also found that unlabeled Tf effectively competes with the conjugated Mx-Tf-FAM formulations. That indicates the conjugate internalization into cells by Tf-TfR endocytosis pathway. The developed nanoplatform can be used as an alternative to conventional nanocarriers for targeted delivery of, e.g., genetic material to MSCs.]]></description>
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