https://www.ebm-journal.org/journals/experimental-biology-and-medicine/sections/clinical-trials RSS Feed for Clinical Trials section in the Experimental Biology and Medicine journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-04-10T08:20:01.203+00:00 60 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10806 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10806 2025-12-08T00:00:00Z Original Research Alexis LeonardJulie Kanter https://www.ebm-journal.org/articles/10.3389/ebm.2025.10624 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10624 2025-07-01T00:00:00Z Original Research Xiaoxi ZhaoYi YangXiangying DuLuguang LiChengbei HouYanning CaiXin Ma 2 was considered a 90-day unfavorable functional outcome. Five (4.9%) of the 103 patients with AIS were lost to follow-up. mtDNA-CN [adjusted β = −0.099, 95% confidence intervals (CIs) = −0.153 ∼ −0.044, p < 0.001] and ROS content (adjusted β = 1.275, 95%CI = 0.885 ∼ 1.665, p < 0.001) were correlated with ICAB. The risk of a 90-day unfavorable functional outcome increased with higher ROS content [adjusted odds ratio (OR) = 1.523, 95%CI = 1.172 ∼ 1.981, p = 0.002] and decreased with higher mtDNA-CN (adjusted OR = 0.911, 95%CI = 0.850 ∼ 0.976, p = 0.008). PBMC mitochondrial dysfunction was found to be independently associated with extensive and severe cervicocephalic atherosclerosis and a 90-day unfavorable functional outcome in patients with AIS, which may provide a novel approach to improving the early identification and risk stratification of cervicocephalic atherosclerosis, along with the prediction of the outcome of atherosclerotic AIS.]]> https://www.ebm-journal.org/articles/10.3389/ebm.2025.10493 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10493 2025-05-01T00:00:00Z Original Research Yingjia HuJian LiMingyu WangXinyi WangJiankang LiHongfei JiXingjian Niu https://www.ebm-journal.org/articles/10.3389/ebm.2025.10447 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10447 2025-02-13T00:00:00Z Original Research Yiyu WangPeijing WuXiaoyan MaoNanjing JiangYu HuangLi ZhangLi LiuXin Tian 10-year-old group. CDKN2A/B deletion occurred more frequently in pediatric patients with T-ALL than in pediatric patients with B-ALL. Patients with CDKN2A/B deletion were more likely to have positive BCR-ABL1 expression combined with IKZF1 deletion. The overall survival (OS) rate was 89.7%, and the event-free survival (EFS) rate was 83.3% in the CDKN2A/B deletion group, which was lower than the OS rate of 97.4% and EFS rate of 93.6% in the non-deletion group. These results suggest that CDKN2A/B deletion may be one of the factors affecting poor prognosis. It provides a new perspective for clinical treatment, risk stratification, and prognostic assessment in pediatric ALL patients.]]> https://www.ebm-journal.org/articles/10.3389/ebm.2024.10137 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10137 2024-04-09T00:00:00Z Original Research Xiaoyu ZhuYin LiuYing HuangHongxia TanMeifang HeDong Wang https://www.ebm-journal.org/articles/10.3389/ebm.2024.10035 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10035 2024-04-08T00:00:00Z Original Research Lijun WangYoupeng JinYuan ChenPing ZhaoXiaohong ShangHaiyan LiuLifeng Sun C and c.183_ 184TA > CT. Children with SDS in China had high incidence rates of chronic diarrhea, cytopenia, short stature, and liver damage. Furthermore, SBDS c.258 + 2T > C and c.183_ 184TA > CT were the most common pathogenic variants in patients with SDS. The diagnosis of SDS can be delayed if the clinical phenotype is not recognized by the health care provider.]]> https://www.ebm-journal.org/articles/10.3389/ebm.2024.10108 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10108 2024-02-29T00:00:00Z Original Research Qiuling ChenYan HongWeiFeng ChenFeng LinJiawei ZengYueting HuangLi ZhangJingwei YaoBing Xu https://www.ebm-journal.org/articles/10.3389/ebm.2024.10021 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10021 2024-01-31T00:00:00Z Original Research Nahid ZareianOleg EreminHardev PandhaRichard BairdVineet KwatraGabriel FuninganaChandan VermaDesmond ChoySteven HargreavesPejvak MoghimiAdrian ShepherdDileep N. LoboJennifer EreminFarzin FarzanehShahram KordastiJames Spicer