Experimental Biology and Medicine | Neuroscience section | New and Recent Articles https://www.ebm-journal.org/journals/experimental-biology-and-medicine/sections/neuroscience RSS Feed for Neuroscience section in the Experimental Biology and Medicine journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-04-22T17:08:11.22+00:00 60 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10827 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10827 <![CDATA[Elevated ApoC3 levels in cerebrospinal fluid predict poor outcomes in patients with aneurysmal subarachnoid hemorrhage]]> 2026-04-17T00:00:00Z Original Research Bin TongJunjie WangJiarui ChenQia ZhangZhouhan XuKaichuang YangXiaomin Chen https://www.ebm-journal.org/articles/10.3389/ebm.2026.10933 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10933 <![CDATA[Genetics of epilepsy]]> 2026-03-19T00:00:00Z Review Kynen PiacentiniAthanasios GaitatzisSulev Kõks https://www.ebm-journal.org/articles/10.3389/ebm.2026.10834 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10834 <![CDATA[A novel de novo ATP2B1 variant causes autosomal dominant intellectual developmental disorder 66 by disrupting calcium homeostasis via impaired membrane trafficking]]> 2026-03-03T00:00:00Z Original Research Huanhuan ZangXiaoyun YangYucai LiuCaiyun MaDawei Yang C, p.Thr714Pro) in the proband. The proband presented with infantile spasms, GDD (Gesell Developmental Quotient: 65–74), and severe growth restriction (height/weight <−2 SD). To investigate the variant’s pathogenicity, the wild-type (WT) and mutant ATP2B1 constructs, N-terminally tagged with mScarlet, were transfected into HEK293T cells. Confocal imaging demonstrated profound cytoplasmic mislocalization of the p.Thr714Pro mutant protein, contrasting sharply with the characteristic plasma membrane localization of WT ATP2B1. Measurement of intracellular Ca2+ levels using Fluo-4 AM showed a significant 2.07-fold increase in basal Ca2+ levels in cells expressing the mutant compared to WT. This finding expands the spectrum of ATP2B1 variants associated with MRD66 and confirms calcium dyshomeostasis as the core pathomechanism. This case of MRD66 demonstrates a very early onset of seizures, consistent with the recognized phenotypic variability and the critical role of PMCA1 in early neurodevelopment.]]> https://www.ebm-journal.org/articles/10.3389/ebm.2026.10835 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10835 <![CDATA[Skeletal muscle reprogramming in peripheral nerve injury: mechanisms, therapeutic roles, and complication management]]> 2026-03-02T00:00:00Z Review Fuqiang LongXiaoru PanAnxin HeXinlu WangZairong WeiShaoying Gao https://www.ebm-journal.org/articles/10.3389/ebm.2026.10712 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10712 <![CDATA[Electrotherapy in the management of neuropathic corneal pain: narrative review]]> 2026-02-06T00:00:00Z Review A. V. ShanmathiMingyi YuChang LiuIsabelle Xin Yu LeeLouis TongYu-Chi Liu https://www.ebm-journal.org/articles/10.3389/ebm.2025.10805 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10805 <![CDATA[Characterisation of the function of a lncRNA containing SINE-VNTR-Alu 67 to regulate the genes at the MAPT locus]]> 2025-11-27T00:00:00Z Original Research Kynen PiacentiniAlexander FröhlichAbigail PfaffSulev Kõks https://www.ebm-journal.org/articles/10.3389/ebm.2025.10491 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10491 <![CDATA[Impact of aging and body mass index on upper extremity motor unit number index and size]]> 2025-07-24T00:00:00Z Brief Communication Lauren I. Gulley CoxNicholas DiasChuan ZhangYingchun ZhangStacey L. Gorniak https://www.ebm-journal.org/articles/10.3389/ebm.2025.10567 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10567 <![CDATA[Mechanisms for reducing/eliminating chronic neuropathic pain with a focus on platelet-rich plasma]]> 2025-06-30T00:00:00Z Mini Review Damien P. KufflerChristian A. Foy https://www.ebm-journal.org/articles/10.3389/ebm.2025.10330 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10330 <![CDATA[Deep brain stimulation for dystonia treatment in cerebral palsy: efficacy exploration]]> 2025-06-09T00:00:00Z Review Haoyang ZhengDuo ZhangWei XiangYong GanZesheng PengYuyi WuPeng Fu https://www.ebm-journal.org/articles/10.3389/ebm.2025.10566 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10566 <![CDATA[Limitations to clinically restoring meaningful peripheral nerve function across gaps and overcoming them]]> 2025-05-27T00:00:00Z Mini Review Christian A. FoyDamien P. Kuffler https://www.ebm-journal.org/articles/10.3389/ebm.2025.10553 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10553 <![CDATA[In vivo silencing of the thalamic CaV3.1 voltage-gated calcium channels demonstrates their region-specific role in anesthetic mediated hypnosis]]> 2025-05-16T00:00:00Z Original Research Tamara Timic StamenicSimon FesehaBrier Fine-RaquetVasilije P. TadicSlobodan M. Todorovic https://www.ebm-journal.org/articles/10.3389/ebm.2025.10549 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10549 <![CDATA[Anesthesia-induced developmental neurotoxicity in the setting of systemic inflammation: the role of microglia]]> 2025-05-16T00:00:00Z Original Research Nemanja UseinovicAdre NewsonMichelle NearStefan MaksimovicBenjamin VolvovitzNidia QuillinanVesna Jevtovic-Todorovic https://www.ebm-journal.org/articles/10.3389/ebm.2025.10545 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10545 <![CDATA[α-linolenic acid-induced facilitation of GABAergic synaptic transmission is mediated via acid-sensing ion channel (ASIC1a) activity in the basolateral amygdala]]> 2025-05-15T00:00:00Z Original Research Volodymyr I. PidoplichkoTaiza H. FigueiredoMaria F. M. BragaAnn M. Marini https://www.ebm-journal.org/articles/10.3389/ebm.2024.10171 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10171 <![CDATA[Subunit-specific mechanisms of isoflurane-induced acute tonic inhibition in dentate gyrus granule neuron]]> 2024-10-28T00:00:00Z Original Research Zhiqiang YuXiaodan ChenZheng LiuRan DingJin Xu https://www.ebm-journal.org/articles/10.3389/ebm.2024.10120 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10120 <![CDATA[Non-coding RNAs and neuroinflammation: implications for neurological disorders]]> 2024-02-28T00:00:00Z Review Yvonne ChenJulia MateskiLinda GeraceJonathan WheelerJan BurlBhavna PrakashCherie SvedinRebecca AmrickBrian D. Adams