Experimental Biology and Medicine | Physiology, Pathophysiology and Mechanisms of Disease section | New and Recent Articles https://www.ebm-journal.org/journals/experimental-biology-and-medicine/sections/physiology-pathophysiology-and-mechanisms-of-disease RSS Feed for Physiology, Pathophysiology and Mechanisms of Disease section in the Experimental Biology and Medicine journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-04-05T15:31:39.510+00:00 60 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10850 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10850 <![CDATA[Lymphatic pumping technique in mice alters blood parameters and metastatic melanoma in an age-dependent manner]]> 2026-03-30T00:00:00Z Original Research Christopher WalshMatthew KirsteinElise WagnerEmily ScottJerome WalshShashank ReddyNathan HoggardArshad AhmadReetobrata BasuSam MathesYanrong QianJohn J. Kopchick https://www.ebm-journal.org/articles/10.3389/ebm.2026.10857 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10857 <![CDATA[Towards a standardized diabetic prolonged wound healing model in hairless SKH1 mice]]> 2026-03-20T00:00:00Z Original Research Elle KoivunotkoJulia MonolaChris S. PridgeonJere LindenRiina HarjumäkiEmrah YatkinMari MadetojaMarjo Yliperttula https://www.ebm-journal.org/articles/10.3389/ebm.2026.10788 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10788 <![CDATA[Intra- and extrapulmonary lipopolysaccharides-induced acute lung injury and pharmacotherapeutic response patterns in ventilated 7-day-old rabbits]]> 2026-02-24T00:00:00Z Original Research Guiyin ZhuangQiang GuSiyu XieXiaojing GuoBo Sun https://www.ebm-journal.org/articles/10.3389/ebm.2026.10755 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10755 <![CDATA[L-Glutamine attenuates peritoneal fibrosis developed in 5-Fluorouracil-treated mice]]> 2026-02-24T00:00:00Z Original Research Juliana Francisca Grossi HelenoLeticia Cristine Cardoso dos SantosIgor Campos FontesMirielly Ranny Almeida Paiva SilvaLucas Barbosa CorreiaNayma Drielly Granato SilvaPedro Henrique Dias Moura PrazeresPedro Pires Goulart GuimarãesDerek W. GilroySilvia Passos AndradePaula Peixoto Campos https://www.ebm-journal.org/articles/10.3389/ebm.2026.10847 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10847 <![CDATA[The gut-retina axis in age-related macular degeneration: immune crosstalk and metabolite production]]> 2026-02-23T00:00:00Z Mini Review Beryl ZhouZaid ParekhChristopher PhungSarah H. RodriguezDimitra Skondra https://www.ebm-journal.org/articles/10.3389/ebm.2026.10810 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10810 <![CDATA[Maternal diet-induced hypercholanemia alters gut microbiota and metabolome in adult female Western diet-fed offspring]]> 2026-01-30T00:00:00Z Original Research Caroline OvadiaSaraid McIlvrideJosca M. SchoonejansKonstantina SpagouMaria Gómez-RomeroAnn SmithGeorgia PapacleovoulouVanya NikolovaPeter H. DixonElaine HolmesJulian R. MarchesiCatherine Williamson 2-fold reduction in CA and dehydrocholic acid levels compared to those from NC-fed mothers. This corresponded with an altered profile of cecal microbiota, with clear separation of microbiotal profiles according to maternal diet in the WD-fed, but not NC-fed, offspring. This observational mouse study has shown that exposure to maternal hypercholanemia can significantly impact the effects of an obesogenic diet on offspring intestinal bile acid metabolism and gut microbiota, likely increasing their vulnerability to metabolic dysfunction when exposed to the “second hit” of an unhealthy postnatal environment.]]> https://www.ebm-journal.org/articles/10.3389/ebm.2025.10489 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10489 <![CDATA[Variational autoencoder enhanced analysis of energy metabolism and autophagy in exercising cardiomyocytes]]> 2025-09-22T00:00:00Z Original Research Liquan ChenYun Yang https://www.ebm-journal.org/articles/10.3389/ebm.2025.10461 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10461 <![CDATA[An approach to evaluate the effect of inflammatory microvesicles on Ca2+ handling in human-induced pluripotent stem cell-derived cardiomyocytes]]> 2025-08-28T00:00:00Z Original Research Dania FischerMishkaat Sha’sha’aJudith SchenzAycan TayanChristina MertensSebastian O. DeckerNadia GallensteinMaximilian DietrichTrim LajqiAnna HafnerMarkus A. WeigandNina D. Ullrich https://www.ebm-journal.org/articles/10.3389/ebm.2025.10524 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10524 <![CDATA[Natural killer cell subpopulations in the peripheral blood of single ventricle/hypoplastic left heart syndrome patients via single-cell RNA sequencing]]> 2025-08-14T00:00:00Z Brief Communication Hui-Qi QuKushagra GoelKayleigh OstbergDiana J. SlaterFengxiang WangJames SnyderCuiping HouGarnet EisterJohn J. ConnollyMichael MarchJoseph T. GlessnerCharlly KaoHakon Hakonarson https://www.ebm-journal.org/articles/10.3389/ebm.2025.10448 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10448 <![CDATA[N-acetyl-L-cysteine improves mitochondrial and oxidative defects in the acadian variant of fanconi syndrome]]> 2025-05-23T00:00:00Z Brief Communication Inas Al-YounisRebeca Martín-JiménezMehtab KhanYann BaussanCaroline JoseYves ThibeaultEtienne Hebert-Chatelain https://www.ebm-journal.org/articles/10.3389/ebm.2025.10490 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10490 <![CDATA[Primary cilia and inflammatory response: unveiling new mechanisms in osteoarthritis progression]]> 2025-04-28T00:00:00Z Mini Review Yuyan SunZiyu LuoYuanyuan FuThaiNamanh NgoWen WangYuanrong WangYing Kong https://www.ebm-journal.org/articles/10.3389/ebm.2025.10605 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10605 <![CDATA[Retraction: Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats]]> 2025-04-10T00:00:00Z Retraction EBM Editorial Office https://www.ebm-journal.org/articles/10.3389/ebm.2025.10204 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10204 <![CDATA[A study on the differences in the gut microbiota and metabolism between male and female mice in different stress periods]]> 2025-02-11T00:00:00Z Original Research Yajun QiaoJuan GuoQi XiaoJianv WangXingfang ZhangXinxin LiangLixin WeiHongtao BiTingting Gao https://www.ebm-journal.org/articles/10.3389/ebm.2024.10121 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10121 <![CDATA[Legumain in cardiovascular diseases]]> 2024-07-22T00:00:00Z Review Lei ZhouJianqiang WuZairong WeiYuehong Zheng https://www.ebm-journal.org/articles/10.3389/ebm.2024.10104 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10104 <![CDATA[Vaporization of perfluorocarbon attenuates sea-water-drowning-induced acute lung injury by deactivating the NLRP3 inflammasomes in canines]]> 2024-04-19T00:00:00Z Original Research Cheng-Cheng SuZhao-Rui ZhangJin-Xia LiuJi-Guang MengXiu-Qing MaZhen-Fei MoJia-Bo RenZhi-Xin LiangZhen YangChun-Sun LiLiang-An Chen https://www.ebm-journal.org/articles/10.3389/ebm.2024.10112 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10112 <![CDATA[Calcium-sensing receptor-mediated macrophage polarization improves myocardial remodeling in spontaneously hypertensive rats]]> 2024-04-05T00:00:00Z Original Research Jiaqi ZhaoNing LuYuanyuan QuWei LiuHua ZhongNa TangJiayi LiLamei WangDongmei XiFang He