Experimental Biology and Medicine | Translational Research section | New and Recent Articles https://www.ebm-journal.org/journals/experimental-biology-and-medicine/sections/translational-research RSS Feed for Translational Research section in the Experimental Biology and Medicine journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-04-19T00:06:32.912+00:00 60 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10907 https://www.ebm-journal.org/articles/10.3389/ebm.2026.10907 <![CDATA[A novel platelet-rich plasma clinically induces reliable, rapid, long-term chronic peripheral neuropathic pain elimination]]> 2026-03-13T00:00:00Z Brief Communication Damien P. KufflerOnix ReyesIvan J. SosaChristian A. Foy https://www.ebm-journal.org/articles/10.3389/ebm.2025.10784 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10784 <![CDATA[Beginning of a new era of synthetic messenger RNA therapeutics: Comprehensive insights on mRNA drug design, development and applications]]> 2025-12-12T00:00:00Z Review Saumya Nishanga HeendeniyaSuxiang ChenSaadia BhattiQurat Ul Ain ZahraKamal RahimizadehBal Hari PoudelStephen D. WiltonRakesh N. Veedu https://www.ebm-journal.org/articles/10.3389/ebm.2025.10782 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10782 <![CDATA[Therapeutic effects of mesenchymal stromal cell secretome in liver fibrosis with acute lung injury]]> 2025-09-30T00:00:00Z Original Research Ane Caroline Ribeiro Novaes MartinsKarina Ribeiro SilvaAnna Carolina de Souza PereiraGustavo Claudino ParisAna Lúcia Rosa NascimentoVerônica AicelesErika Afonso Costa CortezAlessandra Alves TholeSimone Nunes de Carvalho https://www.ebm-journal.org/articles/10.3389/ebm.2025.10735 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10735 <![CDATA[Corrigendum: A double-edged effect of hypoxia on astrocyte-derived exosome releases]]> 2025-07-23T00:00:00Z Correction Yang Jie TsengHui-Ju HuangChien-Hui LinAnya Maan-Yuh Lin https://www.ebm-journal.org/articles/10.3389/ebm.2025.10559 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10559 <![CDATA[A double-edged effect of hypoxia on astrocyte-derived exosome releases]]> 2025-05-21T00:00:00Z Original Research Yang Jie TsengHui-Ju HuangChien-Hui LinAnya Maan-Yuh Lin https://www.ebm-journal.org/articles/10.3389/ebm.2025.10422 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10422 <![CDATA[Gender difference in pre-clinical liver-directed gene therapy with lentiviral vectors]]> 2025-04-25T00:00:00Z Original Research Efrain GuzmanCheen KhooDeirdre O’ConnorGayathri DevarajanSharifah IqballBernard SouberbielleKyriacos MitrophanousYatish Lad https://www.ebm-journal.org/articles/10.3389/ebm.2025.10254 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10254 <![CDATA[The effects of major abdominal surgery on skeletal muscle mitochondrial respiration in relation to systemic redox status and cardiopulmonary fitness]]> 2025-02-21T00:00:00Z Original Research Jia L. StevensHelen T. McKennaMagdalena MinnionAndrew J. MurrayMartin FeelischDaniel S. Martin 10 mL/kg/min) to determine whether redox phenotype was related to cardiorespiratory fitness. No change in mitochondrial oxidative phosphorylation capacity was detected. However, a 26.7% increase in LEAK (uncoupled) respiration was seen after surgery (P = 0.03). Free skeletal muscle cysteine also increased 27.0% (P = 0.003), while S-glutathionylation and other sulfur and nitrogen-based metabolite concentrations remained unchanged. The increase in LEAK was 200% greater in fit patients (P = 0.004). Baseline plasma inflammatory markers, including TNF-⍺ and IL-6 were greater in unfit patients, 96.6% (P = 0.04) and 111.0% (P = 0.02) respectively, with a 58.7% lower skeletal muscle nitrite compared to fit patients. These data suggest that oxidative phosphorylation is preserved during the acute intraoperative period. Increase in free cysteine may demonstrate the muscle’s response to surgical stress to maintain redox balance. The differences in tissue metabolism between fitness groups suggests underlying metabolic phenotypes of frail and resilient patients. For example, increased LEAK in fitter patients may indicate mitochondrial adaptation to stress. Higher baseline measurements of inflammation and lower tissue nitrite in unfit patients, may reflect a state of frailty and susceptibility to postoperative demise.]]> https://www.ebm-journal.org/articles/10.3389/ebm.2025.10390 https://www.ebm-journal.org/articles/10.3389/ebm.2025.10390 <![CDATA[Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials]]> 2025-02-04T00:00:00Z Mini Review Sathish MuthuVibhu Krishnan ViswanathanPrakash Gangadaran https://www.ebm-journal.org/articles/10.3389/ebm.2024.10361 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10361 <![CDATA[Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice]]> 2024-11-19T00:00:00Z Original Research S’Dravious A. DeVeauxSofiya VyshnyaKatherine PropsomOluwabukola T. GbotoshoAsem S. SinghRobert Z. HorningMihika SharmaAnil G. JeggaLiang NiuEdward A. BotchweyHyacinth I. Hyacinth https://www.ebm-journal.org/articles/10.3389/ebm.2024.10246 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10246 <![CDATA[STEMIN and YAP5SA, the future of heart repair?]]> 2024-10-31T00:00:00Z Review Nada BejarSiyu XiaoDinakar IyerAzeez MuiliAdeniyi AdeleyeBradley K. McConnellRobert J. Schwartz https://www.ebm-journal.org/articles/10.3389/ebm.2024.10266 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10266 <![CDATA[Bridging the gap: a translational perspective in spinal cord injury]]> 2024-09-26T00:00:00Z Review Omar Imad HassanSoichiro TakamiyaAzam AsgarihafshejaniMichael G. Fehlings https://www.ebm-journal.org/articles/10.3389/ebm.2024.10142 https://www.ebm-journal.org/articles/10.3389/ebm.2024.10142 <![CDATA[Potential therapeutic effects of peroxisome proliferator-activated receptors on corneal diseases]]> 2024-06-27T00:00:00Z Review Bing Jie ChowIsabelle Xin Yu LeeChang LiuYu-Chi Liu