Correction
Exp. Biol. Med.
Sec. Genomics, Proteomics and Bioinformatics
Correction: Bioinformatics and systems biology approach to identify the pathogenetic link of neurological pain and major depressive disorder
- JH
Jinjing Hu 1
- JF
Jia Fu 1
- YC
Yuxin Cai 1
- SC
Shuping Chen 1
- MQ
Mengjian Qu 2
- LZ
Lisha Zhang 3
- WF
Weichao Fan 1
- ZW
Ziyi Wang 4
- QZ
Qing Zeng 1
- JZ
Jihua ZOU 5
1. Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China
2. Department of Rehabilitation, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, China
3. Department of Clinical Medicine, Suzhou Vocational Health College, Suzhou, China
4. The First School of Clinical Medicine, Southern Medical University, Guangzhou, China
5. Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University,, Guangzhou, China
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Abstract
Adding/removing text The abbreviation "MCC" was incorrectly expanded as "Matthews Correlation Coefficient metric" in the published article. The correct expansion is "Maximal Clique Centrality.". A correction has been made to the section Materials and Methods, Protein-protein interaction network analysis, Paragraph 2:"We also used four algorithms to mine the scores of Co-DEGs in PPI networks that are connected to other PPI network nodes, which included MCC (Maximal Clique Centrality) [33], MNC (the maximal neighborhood coefficient), EPC (edge percolated component), and Closeness. According to our rankings of the Co-DEGs, the top 20 Co-DEGs across the four algorithms were considered as hub genes (hub genes, mRNA)." A correction has been made to the section Results, CytoHubba plug-in identifies the hub genes, Paragraph 1:"We calculated the PPI network using the cytoHubba plugin for Cytoscape using four algorithms: MCC (Maximal Clique Centrality), MNC, EPC (edge percolated component), and Closeness. The top 20 Co-DEGs with the best scores were selected to further identify the hub genes in the Co-DEGs PPI network (Figures 6A-D The abscissa in the bubble chart (F) is GO/KEGG terms, and the length of the bubble distance from the X-axis represents the GeneRatio value of GO terms. Co-DEGs, Common differentially expressed genes; PPI network, Protein-protein interaction network; MCC, Maximal Clique Centrality; MNC, the maximal neighborhood coefficient; EPC, edge percolated component; GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function; KEGG, Kyoto Encyclopedia of Genes and Genomes. The screening criteria for GO/KEGG-enriched entries were p value < 0.05 and FDR value (q.value) < 0.05."
Summary
Keywords
bioinformatics, Gene Expression Omnibus (GEO), major depressive disorder (MDD), neurological pain, Receiver operating characteristic (ROC)
Received
25 July 2026
Accepted
29 September 2026
Copyright
© 2026 Hu, Fu, Cai, Chen, Qu, Zhang, Fan, Wang, Zeng and ZOU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Qing Zeng; Jihua ZOU
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