Experimental Biology and Medicine

Review

Published on 12 Dec 2025

Beginning of a new era of synthetic messenger RNA therapeutics: Comprehensive insights on mRNA drug design, development and applications

in Translational Research

Saumya Nishanga Heendeniya
Suxiang Chen
Saadia Bhatti
Qurat Ul Ain Zahra
Kamal Rahimizadeh
Bal Hari Poudel
Stephen D. Wilton
Rakesh N. Veedu

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10784

2,193 views

Review

Published on 08 Dec 2025

Peripheral artery disease and local drug delivery: a review of disease pathology and drug delivery systems for therapy below the knee

in Pharmacology and Toxicology

Nicole M. Akers
Tammy R. Dugas

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10754

979 views

Original Research

Published on 08 Dec 2025

Clinical data comparison for FDA-approved gene therapies in sickle cell disease

in Clinical Trials

Alexis Leonard
Julie Kanter

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10806

923 views

Original Research

Published on 03 Dec 2025

Mapping microglial mechanisms in Alzheimer’s disease: a comprehensive analysis

in Aging

Xiaofang Wang
Yuqing Guo
Yonghan Zha
Shuling Wang
Weihua Yang
Qianfang Jia

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10808

932 views

Brief Communication

Published on 03 Dec 2025

ApoE COG 133 mimetic peptide improves survival, infection burden, and Clostridioides difficile toxin-A-induced intestinal damage in mice

in Infectious Diseases

Orleâncio G. R. de Azevedo
Jae H. Shin
Rosemayre S. Freire
Gabriella C. V. Ciurleo
Gerly A. C. Brito
Michael P. Vitek
Richard L. Guerrant
Reinaldo B. Oriá
Cirle A. Warren

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10638

649 views

Original Research

Published on 27 Nov 2025

Characterisation of the function of a lncRNA containing SINE-VNTR-Alu 67 to regulate the genes at the MAPT locus

in Neuroscience

Kynen Piacentini
Alexander Fröhlich
Abigail Pfaff
Sulev Kõks

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10805

806 views

Original Research

Published on 13 Nov 2025

The causal relationship between obstructive sleep apnea and otitis media: a bidirectional Mendelian randomization study

in Biomarkers in Regulatory Science

Ruixin Guo
Yifan Zhang
Yijie Chen
Wenqi Sha
Wanyi Kou
Chensi Xu
Yuran Lei
Ningrui Zhang
Liu Yang
Yun Guo

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10540

3,243 views

Original Research

Published on 07 Nov 2025

Curcumin-enhanced elvitegravir therapy mitigates neuroinflammation and cognitive deficits in EcoHIV mice

in Pharmacology and Toxicology

Sandip Godse
Lina Zhou
Namita Sinha
Mohd Salman
Tauheed Ishrat
Santosh Kumar

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10758

4,319 views

Original Research

Published on 21 Oct 2025

Bioinformatics-based screening and validation of ferroptosis-related genes in sepsis and type 2 diabetes mellitus

in AI in Biology and Medicine

Heng Xiao
Zhonghua Ding
Cheng Liu
Xu He
Yanyan Tao

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10612

5,143 views

Original Research

Published on 15 Oct 2025

TIMAP downregulation in Burkitt’s lymphoma reveals key molecules and signaling pathways in B-cell lymphomagenesis

in Genomics, Proteomics and Bioinformatics

Marya Obeidat
Saleh Tadros
Batool Ismail
Ayah Al-Khaldi

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10533

4,666 views

Original Research

Published on 15 Oct 2025

Glaucoma and cardiovascular disease: a bidirectional two-sample Mendelian randomization analysis

in Genomics, Proteomics and Bioinformatics

Dongdong Jin
Jie Sun
Wei Zhang
Mingxuan Zhang
Chengfang Li

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10610

5,187 views

Original Research

Published on 03 Oct 2025

Deciphering the microbiological mechanism of Tongxie Yaofang in treating IBS-D: a multimodal mechanistic study in mice integrating network pharmacology, computational simulation, and 16S rRNA sequencing

in Infectious Diseases

Donglin Yu
Qianghong Tian
Junxi Shen
Leyao Fang
Zhoujin Tan
Ying Cai

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10725

5,598 views

Original Research

Published on 01 Oct 2025

Unveiling the dual role of CD3G: a diagnostic biomarker for depression and its oncogenic implications

in Genomics, Proteomics and Bioinformatics

Hai Gao
Ting Wu
Jihui Xue
Jing Liu
Dongmei Wen
Guanwei Huang

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10599

4,621 views
1 citation

Original Research

Published on 01 Oct 2025

High-fidelity, personalized cardiac modeling via AI-driven 3D reconstruction and embedded silicone rubber printing

in AI in Biology and Medicine

Xuefang Wang
Yixin Li
Zhiqi Liang
Ruxu Du
Ting Song

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10756

4,556 views

Original Research

Published on 30 Sep 2025

Therapeutic effects of mesenchymal stromal cell secretome in liver fibrosis with acute lung injury

in Translational Research

Ane Caroline Ribeiro Novaes Martins
Karina Ribeiro Silva
Anna Carolina de Souza Pereira
Gustavo Claudino Paris
Ana Lúcia Rosa Nascimento
Verônica Aiceles
Erika Afonso Costa Cortez
Alessandra Alves Thole
Simone Nunes de Carvalho

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10782

2,516 views

Original Research

Published on 25 Sep 2025

Multi-omics analysis identifies the unique high-FDCSP basal cells in triple-negative breast cancer

in Genomics, Proteomics and Bioinformatics

Xinya Lu
Zhen Chen
Ying Shao

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10632

5,260 views

Review

Published on 23 Sep 2025

Platelet-rich plasma in peripheral nerve injury repair: a comprehensive review of mechanisms, clinical applications, and therapeutic potential

in Anatomy/Pathology

Kai Shang
Yang Liu
Abdul Qadeer

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10746

3,573 views
1 citation

Original Research

Published on 22 Sep 2025

Variational autoencoder enhanced analysis of energy metabolism and autophagy in exercising cardiomyocytes

in Physiology, Pathophysiology and Mechanisms of Disease

Liquan Chen
Yun Yang

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10489

1,114 views

Original Research

Published on 19 Sep 2025

Prognostic significance and therapeutic implications of redox metabolism-related genes in head and neck squamous cell carcinoma

in Genomics, Proteomics and Bioinformatics

Lina Yang
Jingyu Hai
Jiayi Liu
Shaohua Shen
Lin Su
Juan Sun

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10623

2,210 views

Original Research

Published on 18 Sep 2025

A case study of long-term disease burden in a rural community near an open burn facility

in Population Health

Arundhati Bakshi
Liana Baconguis
Md Abdullah Al-Mamun
Qingzhao Yu
Jennifer Richmond-Bryant
Stephania A. Cormier

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10710

2,538 views

Review

Published on 03 Sep 2025

Unraveling the pharmacological and therapeutic potential of Ranolazine beyond antianginal drug use: a new insight

in Pharmacology and Toxicology

Dhirendra Singh
Joy Awulika Oladimeji-Salami
Abidemi James Akindele

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10604

5,874 views

Original Research

Published on 29 Aug 2025

Integrated analysis of metabolome and microbiome in a mouse model of sodium valproate-induced autism

in Genomics, Proteomics and Bioinformatics

Shuzhen Zhao
Xinyan Zhang
Yanqiu Miao
Xueya Gao
Qiuhua Wan
Wei Qiu
Haixia Si
Yingjie Han
Xiao Du
Yuanyuan Feng

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10452

6,152 views

Original Research

Published on 29 Aug 2025

RNA binding proteins potentially regulate alternative splicing of immune-related genes during the progression of coronary artery disease

in Genomics, Proteomics and Bioinformatics

Yulin Miao
Lei Wang
Gang Zhao
Wei Gou
Shan Chen
Chao Ding
Zongxin Li
Fengli Gao

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10430

5,767 views

Original Research

Published on 28 Aug 2025

An approach to evaluate the effect of inflammatory microvesicles on Ca2+ handling in human-induced pluripotent stem cell-derived cardiomyocytes

in Physiology, Pathophysiology and Mechanisms of Disease

Dania Fischer
Mishkaat Sha’sha’a
Judith Schenz
Aycan Tayan
Christina Mertens
Sebastian O. Decker
Nadia Gallenstein
Maximilian Dietrich
Trim Lajqi
Anna Hafner

Experimental Biology and Medicine

doi 10.3389/ebm.2025.10461

1,212 views

47,786 articles

articles

Beginning of a new era of synthetic messenger RNA therapeutics: Comprehensive insights on mRNA drug design, development and applications

Peripheral artery disease and local drug delivery: a review of disease pathology and drug delivery systems for therapy below the knee

Clinical data comparison for FDA-approved gene therapies in sickle cell disease

Mapping microglial mechanisms in Alzheimer’s disease: a comprehensive analysis

ApoE COG 133 mimetic peptide improves survival, infection burden, and Clostridioides difficile toxin-A-induced intestinal damage in mice

Characterisation of the function of a lncRNA containing SINE-VNTR-Alu 67 to regulate the genes at the MAPT locus

The causal relationship between obstructive sleep apnea and otitis media: a bidirectional Mendelian randomization study

Curcumin-enhanced elvitegravir therapy mitigates neuroinflammation and cognitive deficits in EcoHIV mice

Bioinformatics-based screening and validation of ferroptosis-related genes in sepsis and type 2 diabetes mellitus

TIMAP downregulation in Burkitt’s lymphoma reveals key molecules and signaling pathways in B-cell lymphomagenesis

Glaucoma and cardiovascular disease: a bidirectional two-sample Mendelian randomization analysis

Deciphering the microbiological mechanism of Tongxie Yaofang in treating IBS-D: a multimodal mechanistic study in mice integrating network pharmacology, computational simulation, and 16S rRNA sequencing

Unveiling the dual role of CD3G: a diagnostic biomarker for depression and its oncogenic implications

High-fidelity, personalized cardiac modeling via AI-driven 3D reconstruction and embedded silicone rubber printing

Therapeutic effects of mesenchymal stromal cell secretome in liver fibrosis with acute lung injury

Multi-omics analysis identifies the unique high-FDCSP basal cells in triple-negative breast cancer

Platelet-rich plasma in peripheral nerve injury repair: a comprehensive review of mechanisms, clinical applications, and therapeutic potential

Variational autoencoder enhanced analysis of energy metabolism and autophagy in exercising cardiomyocytes

Prognostic significance and therapeutic implications of redox metabolism-related genes in head and neck squamous cell carcinoma

A case study of long-term disease burden in a rural community near an open burn facility

Unraveling the pharmacological and therapeutic potential of Ranolazine beyond antianginal drug use: a new insight

Integrated analysis of metabolome and microbiome in a mouse model of sodium valproate-induced autism

RNA binding proteins potentially regulate alternative splicing of immune-related genes during the progression of coronary artery disease

An approach to evaluate the effect of inflammatory microvesicles on Ca2+ handling in human-induced pluripotent stem cell-derived cardiomyocytes